Within our grasp: Visually guided reaching in prodromal Alzheimer's disease

Recent evidence has implicated the precuneus of the medial parietal lobe as one of the first brain areas to show pathological changes in Alzheimer’s disease (AD). Damage to the precuneus through focal brain injury is associated with impaired visually-guided reaching, particularly for objects in peripheral vision. This raises the hypothesis that peripheral misreaching may be detectable in patients with prodromal AD. The aim of this study is to assess the frequency and severity of peripheral misreaching in patients with mild cognitive impairment (MCI) and AD. We also aim to test other behaviours associated with parietal lobe function such as attention and online-correction.

近期的研究证据表明，内侧顶叶的枕叶可能是阿尔茨海默病（AD）中最早出现病理改变的脑区之一。枕叶的损伤，尤其是通过局灶性脑损伤引起的，与视觉引导下的伸手行为受损有关，尤其是对于视野边缘的物体。这提出了一个假设，即视野边缘的误触可能在阿尔茨海默病前驱期患者中可被检测到。本研究旨在评估轻度认知障碍（MCI）和阿尔茨海默病患者视野边缘误触的频率和严重程度。此外，我们还将测试与顶叶功能相关的其他行为，如注意力和在线校正。（Recent evidence has implicated the precuneus of the medial parietal lobe as one of the first brain areas to show pathological changes in Alzheimer’s disease (AD). Damage to the precuneus through focal brain injury is associated with impaired visually-guided reaching, particularly for objects in peripheral vision. This raises the hypothesis that peripheral misreaching may be detectable in patients with prodromal AD. The aim of this study is to assess the frequency and severity of peripheral misreaching in patients with mild cognitive impairment (MCI) and AD. We also aim to test other behaviours associated with parietal lobe function such as attention and online-correction.）