DNA methylation alterations of driver genes in blood of high-altitude pulmonary edema ( RRBS)

Epigenetics may play an important role in the occurrence and development of high-altitude pulmonary edema. To investigate the DNA methylation driving genes associated with high-altitude pulmonary edema, we also performed reduced representation bisulfite sequencing (RRBS) for blood identify differences of DNA methylation status of 10 HAPE patients and 10 healthy volunteers. Overall design: We performed reduced representation bisulfite sequencing (RRBS) for blood of 10 HAPE patients and 10 healthy volunteers. All of the participants and health care volunteers were Han Chinese people between the ages of 18 and 65 who had travelled to Tibet.