Data related to article "Cytokine profile in striated muscle laminopathies: new promising biomarkers for disease prediction"

This database includes a comprehensive profile of circulating pro- and anti-inflammatory molecules (cytokines, chemokines and growth factors) obtained from a group of 53 patients with muscular laminopathy, 10 with non-muscular laminopathy, 22 with other muscular disorders and 35 healthy controls. Data obtained by Luminex multiple immune-assay identify TGF-2, IL-17 and G-CSF as potential biomarkers in discriminating  between muscle-related laminopathy and healthy subjects. The different expression  of IL-1, IL-4 and IL-8 among the different forms of laminopathy provides a new hint for the understanding of the pathogenic mechanisms underlying the diverse phenotypes caused by LMNA mutations.