COPI-mediated anterograde transport

The ERGIC (ER-to-Golgi intermediate compartment, also known as vesicular-tubular clusters, VTCs) is a stable, biochemically distinct compartment located adjacent to ER exit sites (Ben-Tekaya et al, 2005; reviewed in Szul and Sztul, 2011). The ERGIC concentrates COPII-derived cargo from the ER for further anterograde transport to the cis-Golgi and also recycles resident ER proteins back to the ER through retrograde traffic. Both of these pathways appear to make use of microtubule-directed COPI-coated vesicles (Pepperkok et al, 1993; Presley et al, 1997; Scales et al, 1997; Stephens and Pepperkok, 2002; Stephens et al, 2000; reviewed in Lord et al, 2001; Spang et al, 2013).

ERGIC（ER至高尔基中间区室，亦称囊泡-管状簇，VTCs）是一种稳定且生化特性独特的区室，位于ER出口位点邻近处（Ben-Tekaya 等，2005；参见 Szul 和 Sztul，2011 年综述）。ERGIC 汇聚由 COPII 分泌的货物从 ER，以供进一步向前运输至顺式高尔基区，并亦通过逆向交通将驻留的 ER 蛋白重新循环回 ER。这两条途径似乎均利用了由微管导向的 COPI 包被的囊泡（Pepperkok 等，1993；Presley 等，1997；Scales 等，1997；Stephens 和 Pepperkok，2002；Stephens 等，2000；参见 Lord 等，2001；Spang 等，2013 年综述）。