Neuron-astroglial communication: Exosomal heparanase isoforms released from astrocyte modulate synaptic strength

This files contains data to support the following experimental results:Results presented in this study provide evidences that heparanase 2 and astrocytes heparanase associated ADEV in response to NMDA stimulation exhibit inhibitory effect to synaptic plasticity by enhancing the bulk internalization of surface AMPA receptors and Syndecan 3 from the neuronal surface. This study is also the first time revealing the microstructure of heparanase associated exosome derived from astrocyte.