SGC-GAK-1: A Chemical Probe for Cyclin G Associated Kinase (GAK)
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https://figshare.com/articles/dataset/SGC-GAK-1_A_Chemical_Probe_for_Cyclin_G_Associated_Kinase_GAK_/7772222
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资源简介：
We describe SGC-GAK-1
(11), a potent, selective, and
cell-active inhibitor of cyclin G-associated kinase (GAK), together
with a structurally related negative control SGC-GAK-1N (14). 11 was highly selective in an in vitro kinome-wide
screen, but cellular engagement assays defined RIPK2 as a collateral
target. We identified 18 as a potent RIPK2 inhibitor
lacking GAK activity. Together, this chemical probe set can be used
to interrogate GAK cellular biology.
创建时间：
2019-02-26
