Subject characteristics for early-onset Alzheimer’s disease (AD) patients (disease onset <65 years), late-onset AD patients (disease onset ≥65 years), young (<65 years) - and old (≥65 years) healthy age-matched controls (HC).

Data are presented as means ± standard deviations.
Mini Mental State Examination (MMSE) score and Normalized Gray Matter Volume (NGMV) in litre (L). Level of education using Verhage’s classification [44]. Not applicable (n.a.). Alzheimer’s disease (AD). Healthy controls (HC).
*All AD patients that were on AD medication used Reminyl, with exception of 1 early-onset AD patient, who used Exelon. Both are competitive and reversible cholinesterase inhibitors.
♦significantly different from early-onset AD.
¶significantly different from late-onset AD.
†significantly different from young controls.
‡significantly different from old controls.