Subject characteristics for early-onset Alzheimer’s disease (AD) patients (disease onset <65 years), late-onset AD patients (disease onset ≥65 years), young (<65 years) - and old (≥65 years) healthy age-matched controls (HC).

Data are presented as means ± standard deviations. Mini Mental State Examination (MMSE) score and Normalized Gray Matter Volume (NGMV) in litre (L). Level of education using Verhage’s classification [44]. Not applicable (n.a.). Alzheimer’s disease (AD). Healthy controls (HC). *All AD patients that were on AD medication used Reminyl, with exception of 1 early-onset AD patient, who used Exelon. Both are competitive and reversible cholinesterase inhibitors. ♦significantly different from early-onset AD. ¶significantly different from late-onset AD. †significantly different from young controls. ‡significantly different from old controls.