Local IL-10 delivery modulates the immune response and enhances repair of volumetric muscle loss muscle injury

To explore the impact of targeting IL-10 signaling, tibialis anterior (TA) VML injuries were created and then treated in Sprague Dawley rats using an autologous minced muscle regenerative medicine repair strategy in combination with delayed exogenous IL-10 delivery. We then performed gene expression profiling analysis using data obtained from RNA-seq from rat muscles (n=4 for IL-10 treatment, n=4 for PBS control , and n=4 for uninjured control) at day 14 post injury Comparative gene expression profiling analysis of RNA-seq data from rat Tibialis anterior muscle tissues between unjured, Pbs abd IL-10 treatment