DISCOVERY OF CELL-ACTIVE PHENYL-IMIDAZOLE PIN1 INHIBITORS BY STRUCTURE-GUIDED FRAGMENT EVOLUTION

DISCOVERY OF CELL-ACTIVE PHENYL-IMIDAZOLE PIN1 INHIBITORS BY STRUCTURE-GUIDED FRAGMENT EVOLUTION Descriptor: 2-phenyl-1H-imidazole-4-carboxylic acid, DODECAETHYLENE GLYCOL, PEPTIDYL-PROLYL CIS-TRANS ISOMERASE NIMA-INTERACTING 1 Authors: Potter, A, Oldfield, V, Nunns, C, Fromont, C, Ray, S, Northfield, C.J, Bryant, C.J, Scrace, S.F, Robinson, D, Matossova, N, Baker, L, Dokurno, P, Surgenor, A.E, Davis, B.E, Richardson, C.M, Murray, J.B, Moore, J.D. Deposit date: 2010-08-25 Release date: 2011-01-12 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Discovery of Cell-Active Phenyl-Imidazole Pin1 Inhibitors by Structure-Guided Fragment Evolution. Bioorg.Med.Chem.Lett., 20, 2010基于结构引导片段演化的细胞活性苯基咪唑类PIN1抑制剂发现 描述项：2-苯基-1H-咪唑-4-羧酸、十二聚乙二醇、肽基脯氨酰顺反异构酶NIMA相互作用蛋白1（Peptidyl-Prolyl Cis-Trans Isomerase NIMA-Interacting 1） 作者：Potter A, Oldfield V, Nunns C, Fromont C, Ray S, Northfield C.J, Bryant C.J, Scrace S.F, Robinson D, Matossova N, Baker L, Dokurno P, Surgenor A.E, Davis B.E, Richardson C.M, Murray J.B, Moore J.D 提交日期：2010-08-25 发布日期：2011-01-12 最后修改日期：2023-12-20 研究方法：X射线衍射（分辨率1.8埃） 引用信息：《基于结构引导片段演化的细胞活性苯基咪唑类PIN1抑制剂发现》，《Bioorg.Med.Chem.Lett.》，20卷，2010年