Systematic review data of whole grains versus placebo or refined grains on cardiovascular disease risk factors.

This dataset comprises data extracted 29 publications which were included
in a systematic review and meta-analysis of randomised controlled trials
which compared whole grain versus refined grain dietary intake on
cardiovascular disease risk factors. There were 80 cardiovascular disease
risk factor outcome measures considered in the review. Data were extracted
by one investigator and checked for accuracy twice. Study characteristics
were extracted, including study design, sample population, and details of
the intervention and control conditions. Outcome data were extracted for
the intervention and comparator groups were baseline, change, and
follow-up variables, variable units, and statistical significance over
time and between groups. Adverse events were also recorded. The 29
included studies measured and reported on 40 outcomes. Extracted outcomes
can be grouped as haemodynamics (reported by 12 studies), body composition
(15 studies), blood lipids (18 studies), glycaemic and/or insulin markers
(19 studies), inflammatory markers (21 studies), oxidative stress markers
(6 studies), and cardiovascular comorbidity incidence (2 studies).
Rigorous analysis, including meta-regression, may be carried out using
this data to evaluate the cause and effect relationship of whole grains on
cardiovascular risk by considering confounding variables on pooled
outcomes.