Activation of GPBAR1 by BAR501, a selective synthetic agonist, reduces vascular inflammation and atherosclerosis in a mouse model of NAFLD-related cardiovascular disease

The purpose of this study was to evaluate the effect of GPBAR1 activation in a mouse model of atherosclerosis. For this study, Apolipoprotein E deficient mice (ApoE−/−), a standard model of atherosclerosis, were fed with HFD-F alone or in combination with BAR501 for 14 weeks and then sacrificed. The transcriptome analysis of the aorta showed an anti-inflammatory activity of BAR501 that downregulated the expression of many genes belonging to inflammatory pathways.本研究旨在评估G蛋白偶联胆汁酸受体1 (GPBAR1)激活在动脉粥样硬化小鼠模型中的效应。本研究采用动脉粥样硬化经典模型——载脂蛋白E缺陷小鼠（Apolipoprotein E deficient mice, ApoE−/−），将其分为两组，分别单独饲喂高脂饲料（HFD-F）或联合给予BAR501，持续干预14周后实施安乐死。对小鼠主动脉的转录组分析结果显示，BAR501可发挥抗炎活性，下调多条炎症通路上多个基因的表达水平。