Digitoxin Inhibits Epithelial-to-Mesenchymal-Transition in Hereditary Castration Resistant Prostate Cancer

We have previously reported that the cardenolide drug digitoxin blocks TNFα/NFκB-driven proinflammatory signaling. We therefore hypothesized that digitoxin might break the collaborative process between NFκB and TGFβ by also inhibiting expression of TGFBR2. We therefore tested whether TGFβ-driven EMT and resulting metastases would be suppressed.我们此前已有研究成果表明，强心苷类（cardenolide）药物洋地黄毒苷（digitoxin）可阻断肿瘤坏死因子α（TNFα）/核因子κB（NFκB）介导的促炎信号通路。基于此我们提出假说：洋地黄毒苷或可通过同时抑制转化生长因子β受体II（TGFBR2）的表达，打破NFκB与转化生长因子β（TGFβ）之间的协同交互过程。为此我们设计实验，验证转化生长因子β诱导的上皮间质转化（EMT）及其所导致的肿瘤转移是否会受到抑制。