Molecular profile of apocrine glands in hidradenitis suppurativa

Molecular taxonomy and key signaling pathways of apocrine glands of patients with hidradenitis suppurativa were studied by whole transcriptome profiling. Dysregulated genes were detected by comparing lesional and non lesional skin obtained from male and female HS patients using the Agilent array platform. Total RNA was obtained from apocrine glands isolated by laser capture microscopy from full thickness skin specimens taken from both lesional and non lesional sites in 16 patients (8 male 8 female) diagnosed with Hurley stage II hidradenitis suppurativa.