Maternal transcription factor TCF12 mediates fertilization and zygotic genome activation during early embryonic development. Maternal transcription factor TCF12 mediates fertilization and zygotic genome activation during early embryonic development

To investigate the physiological function of TCF12 in oocyte maturation and preimplantational development, we crossed Tcf12fl/fl mice with Gdf9-Cre mice to specifically delete Tcf12 from the primordial follicle stage. We then performed gene expression profiling analysis using data obtained from RNA-seq on Tcf12fl/fl and Tcf12fl/fl;Gdf9-Cre growing GV oocytes (gGO), fully grown GV oocytes (fGO), embryos at 2-cell and 4-cell stage. Overall design: Comparative gene expression profiling analysis of RNA-seq data for Tcf12fl/fl and Tcf12fl/fl;Gdf9-Cre samples.