Mutation architectures define a WNT-MAPK transcriptional landscape in colorectal cancer

Data and code resources for “Mutation architectures define a WNT-MAPK transcriptional landscape in colorectal cancer” (Espinosa et al.). This repository contains derived data from the study, including MuVI embeddings and factor loadings, genotype–phenotype map summaries, cohort-wide genomic feature prevalences, group-level transcriptional and H&E summaries, sample-level H&E composition features, and CMS probabilities. The underlying patient-level Caris Life Sciences molecular and clinical data were accessed under a data licensing agreement and cannot be redistributed. A fully synthetic cohort is also provided to enable execution and inspection of the accompanying analysis workflow without access to the licensed data. The synthetic data do not represent real patients and are intended for methodological demonstration only. See the README for detailed file descriptions and the Related identifiers for the accompanying code releases. Access note: Files are temporarily restricted during manuscript review and will be made publicly available upon posting of the associated preprint.