Data from: Selective breeding and selection mapping using a novel wild-derived heterogeneous stock mice revealed two closely-linked loci for tameness

Tameness is a major behavioral factor for domestication, and can be
divided into two potential components: motivation to approach humans
(active tameness) and reluctance to avoid humans (passive tameness). We
identified genetic loci for active tameness through selective breeding,
selection mapping, and association analysis. In previous work using
laboratory and wild mouse strains, we found that laboratory strains were
predominantly selected for passive tameness but not active tameness during
their domestication. To identify genetic regions associated with active
tameness, we applied selective breeding over 9 generations for contacting,
a behavioural parameter strongly associated with active tameness. The
prerequisite for successful selective breeding is high genetic variation
in the target population, so we established and used a novel resource,
wild-derived heterogeneous stock (WHS) mice from eight wild strains. The
mice had genetic variations not present in other outbred mouse
populations. Selective breeding of the WHS mice increased the contacting
level through the generations. Selection mapping was applied to the
selected population using a simulation based on a non-selection model and
inferred haplotype data derived from single-nucleotide polymorphisms. We
found a genomic signature for selection on chromosome 11 containing two
closely linked loci.