Top 50 gene transcripts increased by RNA sequencing in sessile serrated polyps (SSA/P) in serrated polyposis patients compared to controls.

Fold change is reported for seven right-sided sessile serrated polyps, from five serrated polyposis patients (age 26–62 years, 3 female and 2 male), compared to surrounding uninvolved colon and normal colon from healthy volunteers (controls, n = 8). Fold-change (Fold) and false discovery rate (FDR) for specific gene sequencing reads are provided (see Methods). The fold change and FDR in sex matched adenomatous polyps (AP) (age 55–79 years, three right-sided and four left-sided) with low dysplasia compared to uninvolved colon (n = 7) from a previous microarray study are provided (Sabates-Bellver, et al., 2007). Genes with an asterisk have not been previously reported to be differentially expressed in SSA/Ps. “na” denotes transcripts not analyzed in the microarray study.