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Mesenchymal stem cells from myelodysplastic syndromes are functionally and genomically abnormal

ChEBI2010-05-25 更新2026-07-21 收录

骨髓增生异常综合征分子病理

干细胞功能基因组学

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-10822 数据链接链接失效反馈

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Mesenchymal stem cells from myelodysplastic syndromes are functionally and genomically abnormal

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创建时间：

2010-05-25

干细胞功能基因组学

基因敲低转录组分析

To study the effect of knockdown of Cxxc5 on stem/progenitor cells, we used retrovirus to knockdown Cxxc5 expression in the LSK cells. We used this as a surrogate to study the function of Cxxc5 in mou

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Understanding Early Stage Myelodysplastic Syndrome Pathobiology

骨髓增生异常综合征分子病理

造血干细胞分子特征

Delineating key HSC regulators is of significant interest for informing the treatment of hematologic malignancy. While HSC activity is enhanced by overexpression of SKI, the transforming growth factor

NIAID Data Ecosystem40

ChIP-seq in MEG3+ and MEG3- hIPSCs. Homo sapiens

表观遗传调控

干细胞功能基因组学

In this experiment we sought to identify region with differential PRC2, JARID2, and H3K27me3 occupancy in human induced pluripotent stem cell lines with silenced or expressed MEG3 locus to indirectly

NIAID Data Ecosystem40

Control of hematopoietic stem cell quiescence by the E3 Ubiquitin Ligase Fbw7. Mus musculus

造血干细胞调控

干细胞功能基因组学

Ubiquitination is a post-translational mechanism of control of diverse cellular processes. We focus here on the ubiquitin ligase Fbw7, a recently identified hematopoietic tumor suppressor that can tar

NIAID Data Ecosystem50

DNAseq analysis of a genome-wide loss-of-function CRISPR/Cas9 library established in haploid human embryonic stem cells (hESCs)

干细胞功能基因组学

基因编辑筛选

The maintenance of pluripotency requires coordinated expression of a set of essential genes. Using our recently established haploid human pluripotent stem cells (hPSCs), we generated a genome-wide los

NIAID Data Ecosystem40

Mesenchymal stem cells from myelodysplastic syndromes are functionally and genomically abnormal

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