Small-Molecule-Induced ERBB4 Activation to Treat Heart Failure

To determine the transcriptomic changes of small-molecule-induced activation of ERBB4 in heart failure, we tested the effects of the two small molecules (NRG1 and EF-1) of ERBB4 agonists on the HCF (human cardiac fibroblasts) model. The transcriptional profiles of mRNA in these samples will be measured with high throughput technology. Changes in transcriptional profiles between the activation of EF-1 and NRG1 will be compared. 9 HCF samples were analyzed. 3 from control, 3 from NRG1, and 3 from EF-1.