Potent and Selective Inhibitors of PI3K-delta: Obtaining Isoform Selectivity from the Affinity Pocket and Tryptophan Shelf
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Potent and Selective Inhibitors of PI3K-delta: Obtaining Isoform Selectivity from the Affinity Pocket and Tryptophan Shelf Descriptor: 2-(1-{[2-(2-aminopyrimidin-5-yl)-4-(morpholin-4-yl)pyrido[3,2-d]pyrimidin-6-yl]methyl}piperidin-4-yl)propan-2-ol, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform Authors: Murray, J.M. Deposit date: 2012-05-02 Release date: 2013-04-17 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.94 Å) Cite: Potent and selective inhibitors of PI3K-delta: obtaining isoform selectivity from the affinity pocket and tryptophan shelf Bioorg.Med.Chem.Lett., 22, 2012
磷脂酰肌醇3-激酶δ亚型（PI3K-delta）强效选择性抑制剂：从结合口袋与色氨酸保守架获取亚型选择性：2-(1-{[2-(2-氨基嘧啶-5-基)-4-(4-吗啉基)吡啶并[3,2-d]嘧啶-6-基]甲基}哌啶-4-基)丙-2-醇，磷脂酰肌醇4,5-二磷酸3-激酶催化亚基γ亚型
作者：默里（Murray, J.M.）
存档日期：2012-05-02
发布日期：2013-04-17
最后修改日期：2023-09-13
实验方法：X射线衍射（分辨率2.94埃）
引用文献：Potent and selective inhibitors of PI3K-delta: obtaining isoform selectivity from the affinity pocket and tryptophan shelf, 《生物有机与药物化学快报》（Bioorg.Med.Chem.Lett.）, 22卷, 2012年
创建时间：
2012-05-02
