Enhancer-promoter interactions are reconfigured through the formation of long-range multiway hubs as mouse ES cells exit pluripotency
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BACH1 Recruits NANOG and Histone H3 Lysine 4 Methyltransferase MLL/SET1 Complexes to Regulate Enhancer-promoter Activity and Maintains Pluripotency
Maintenance of stem-cell identity requires proper regulation of enhancer activity. Both transcription factors OCT4/SOX2/NANOG and histone methyltransferase complexes MLL/SET1 were shown to regulate en
NIAID Data Ecosystem80
Cell type and expression independent spatial enhancer-promoter proximity. Cell type and expression independent spatial enhancer-promoter proximity
We explored the relationship between enhancer-promoter pairs, spatial proximity and cell specific gene expression Overall design: We performed HiChIP using the H3K27ac antibody in two cell lines, Endo
NIAID Data Ecosystem40
The impact of genomic distance on enhancer-promoter interactions at the CFTR locus.
We identified and characterized multiple cell-type selective enhancers of the CFTR gene promoter in previous work and demonstrated active looping of these elements to the promoter. Here we address the
NIAID Data Ecosystem10
Enhancer-promoter interactions in acheiropodia patient's cells
Acheiropodia, congenital limb truncation, is associated with homozygous deletions in the LMBR1 gene around ZRS, an enhancer regulating SHH during limb development. How these deletions leads to this ph
NIAID Data Ecosystem60
Temporal constraints on enhancer usage and enhancer-promoter connectivity shape the regulation of limb gene transcription [ChIP-seq]
The repertoire of enhancers orchestrating gene expression during embryonic development shapes the forms and functions of organs. Within regulatory landscapes, enhancers control their target genes thro
NIAID Data Ecosystem20
