Biased Signaling by Mutant EGFR Underlies Cell of Origin for Lung Adenocarcinoma and Dependence on Protein Kinase C

Datasets for the GitHub repo - https://github.com/pallavisurana1/tumor_deconvolution_applicationThe reference for the data is sourced from iHLCA but has been further processed to suit our specific use case. Notably, mutations in EGFR and KRAS were identified. Within EGFR, the exon 19 deletions (del745-750, 45%) and exon 21 substitutions (L858R, 40-45%) are of particular significance, as referenced from the GDC portal.