Longitudinal optic neuritis-unrelated visual evoked potential changes in NMO spectrum disorders

Objective: To investigate, if neuromyelitis optica spectrum disorder (NMOSD) patients develop subclinical visual pathway impairment independent of acute attacks. Methods: 548 longitudinally assessed full-field visual evoked potentials (VEP) of 167 NMOSD patients from 16 centers were retrospectively evaluated for changes of P100-latencies and P100-N140-amplitudes. Rates of change in latencies (RCL) and amplitudes (RCA) over time were analyzed for each individual eye using linear regression and compared using generalized estimating equation models. Results: The rates of change in the absence of optic neuritis (ON) for minimal VEP intervals of ≥3 months between baseline and last follow-up were +1.951ms/year (N=101 eyes; SD=6.274; p=0.012) for the P100-latencies and -2.149µV/year (N=64 eyes; SD=5.013; p=0.005) for the P100-N140-amplitudes. For minimal VEP intervals of ≥12 months the RCL was +1.768ms/year (N=59 eyes; SD=4.558; p=0.024) and the RCA was -0.527µV/year (N=44 eyes; SD=2.123; p=...研究目的：旨在探讨视神经脊髓炎谱系疾病（neuromyelitis optica spectrum disorder, NMOSD）患者是否会在未发生急性发作的情况下出现亚临床视觉通路损害。 方法：本研究回顾性分析了来自16个中心的167例NMOSD患者的548次纵向随访评估全视野视觉诱发电位（full-field visual evoked potentials, VEP），针对P100潜伏期与P100-N140波幅的变化展开分析；采用线性回归法对每只眼的潜伏期变化率（RCL）与波幅变化率（RCA）的随时间变化趋势进行分析，并通过广义估计方程模型完成组间比较。 结果：在基线至末次随访的最短VEP间隔时间≥3个月、且无视神经炎（optic neuritis, ON）发作的受试者中，P100潜伏期的变化率为+1.951ms/年（N=101只眼；标准差SD=6.274；p=0.012），P100-N140波幅的变化率为-2.149μV/年（N=64只眼；标准差SD=5.013；p=0.005）。当最短VEP间隔时间≥12个月时，潜伏期变化率（RCL）为+1.768ms/年（N=59只眼；标准差SD=4.558；p=0.024），波幅变化率（RCA）为-0.527μV/年（N=44只眼；标准差SD=2.123；p=...