FBAT analysis under dominant model of inheritance for associations between <i>ABCA4</i> and <i>COL2A1</i> and congenital toxoplasmosis in the NCCCTS child-parent trios.

A positive Z score indicates association with disease; a negative Z score indicates the non-associated allele; only Z scores for P<0.1 are shown, P≤0.05 is shown in bold. Significant associations in the NCCCTS cohort for COL2A1 with infants with brain lesions likely reflect the larger proportion of children with both brain and eye lesions. There were too few children with brain only or eye only lesions to analyze these as separate groups. The use of trios in the NCCCTS cohort was robust to ethnic admixture. aDetails of allele frequencies provided in Table S1. bOnly significant under dominant model, disease allele recessive; using case/pseudo-control analysis, OR for heterozygote compared to homozygous disease allele is 0.37 (95% confidence intervals: 0.14–0.92; P = 0.032). cAlso significant under additive model; OR for carrying disease allele is 2.45 (1.22–4.94; P = 0.012) for rs2276454 and 2.6 (1.25–5.39; P = 0.010) for rs1635544. Table S9 provides full details of the genotypes of child/parent trios, including phenotype of the child.