The complex of murine cyclooxygenase-2 with a conjugate of indomefathin and podophyllotoxin, N-{(succinylpodophyllotoxinyl)but-4-yl}-2-{1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl}acetamide

The complex of murine cyclooxygenase-2 with a conjugate of indomefathin and podophyllotoxin, N-{(succinylpodophyllotoxinyl)but-4-yl}-2-{1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl}acetamide Descriptor: (5S,5aS,8aS,9S)-8-oxo-9-(3,4,5-trimethoxyphenyl)-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl 4-{[4-({[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetyl}amino)butyl]amino}-4-oxobutanoate, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Xu, S, Uddin, M.J, Banerjee, S, Marnett, L.J. Deposit date: 2014-02-13 Release date: 2015-04-08 Last modified: 2024-11-06 Method: X-RAY DIFFRACTION (2.11 Å) Cite: Antitumor Activity of Cytotoxic Cyclooxygenase-2 Inhibitors. Acs Chem.Biol., 11, 2016

鼠源环氧合酶-2（murine cyclooxygenase-2）与indomefathin及鬼臼毒素（podophyllotoxin）缀合物形成的复合物：N-{(琥珀酰基鬼臼毒素基)丁-4-基}-2-{1-(4-氯苯甲酰基)-5-甲氧基-2-甲基-1H-吲哚-3-基}乙酰胺。结构描述符：(5S,5aS,8aS,9S)-8-氧代-9-(3,4,5-三甲氧基苯基)-5,5a,6,8,8a,9-六氢呋喃并[3',4':6,7]萘并[2,3-d][1,3]二氧杂环戊烯-5-基 4-{[4-({[1-(4-氯苯甲酰基)-5-甲氧基-2-甲基-1H-吲哚-3-基]乙酰基}氨基)丁基]氨基}-4-氧代丁酸酯、2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖（2-acetamido-2-deoxy-beta-D-glucopyranose）、2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖-(1-4)-2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖等。作者：Xu, S、Uddin, M.J、Banerjee, S、Marnett, L.J。提交日期：2014-02-13，发布日期：2015-04-08，最后修改日期：2024-11-06。实验方法：X射线衍射（X-RAY DIFFRACTION，分辨率2.11埃）。引用文献：《细胞毒性环氧合酶-2抑制剂的抗肿瘤活性》，发表于ACS Chem.Biol.，第11卷，2016年。