首页/数据集/TP63 fusions drive multicomplex enhancer rewiring, lymphomagenesis, and PRC2 dependence

TP63 fusions drive multicomplex enhancer rewiring, lymphomagenesis, and PRC2 dependence

NIAID Data Ecosystem2026-05-01 收录

启动子-增强子互作

T细胞淋巴瘤

数据链接：

https://www.ncbi.nlm.nih.gov/sra/SRP453427 数据链接链接失效反馈

官方服务：

资源简介：

Identification of enhancer-promoter contacts in the T-lymphoma cell line SMZ1 Overall design: Applying H3K27ac HiChIP to identify enhancer-promoter interactions in the T-lymphoma cell line SMZ1

应用场景：

创建时间：

2023-08-05

T细胞发育阶段特异性调控

T细胞淋巴瘤

T cell factor 1 (TCF1; encoded by Tcf7) plays a critical role in T cell development and functions as a tumor suppressor by repressing the expression of LEF1 in the thymus. Here we reported the stage-s

NIAID Data Ecosystem80

small-RNA-Seq in human T-cell lymphoblastic lymphoma samples and control thymuses

T细胞淋巴瘤

小RNA测序

Precursor T-cell lymphoblastic neoplasms are aggressive haematological neoplasm that most often manifest with extensive marrow and blood affectation (T-cell acute lymphoblastic leukaemia or T-ALL) or

NIAID Data Ecosystem70

DataSheet_1_Case Report: An unclassified T cell lymphoma subtype with co-expression of TCR αβ and γ chains revealed by single cell sequencing.xlsx

T细胞淋巴瘤

单细胞转录组学

BackgroundT cell lymphomas (TCL) are a group of heterogeneous diseases with over 40 subtypes. In this study, we identified a novel TCL subtype which was featured by a unique T cell receptor (TCR) pres

NIAID Data Ecosystem60

THZ1 targeting CDK7 suppresses STAT transcriptional activity and sensitizes T-cell lymphomas to BCL2 inhibitors

T细胞淋巴瘤

转录因子靶向

Peripheral T-cell lymphomas (PTCL) are aggressive diseases with poor response to chemotherapy and dismal survival. Identification of effective strategies to target PTCL biology represents an urgent ne

NIAID Data Ecosystem70

The Pol II Pre-Initiation Complex (PIC) Influences Mediator Binding but Not Promoter-Enhancer Looping [promoter_capture_Hi-C]. The Pol II Pre-Initiation Complex (PIC) Influences Mediator Binding but Not Promoter-Enhancer Looping [promoter_capture_Hi-C]

转录调控机制

启动子-增强子互作

Knowledge of how Mediator and TFIID crosstalk contributes to promoter-enhancer (P-E) communication is important for elucidating the mechanism of enhancer function. We conducted an shRNA knockdown scre

NIAID Data Ecosystem60

TP63 fusions drive multicomplex enhancer rewiring, lymphomagenesis, and PRC2 dependence

资源简介：

相关数据集