Multiple SNP models of bone mineral density change after hematopoietic cell transplantation.

Footnote: R2, coefficient of determination, provides an estimate of the proportion of BMD change that can be accounted for by all covariates in the model. ΔR2 denotes the increase in model accountability by adding SNP(s) to the base clinical risk factor model. All R2 are adjusted by the number of covariates in the model. A higher ΔR2 suggests an important role of genetics in addition to clinical risk factors for HCT-inducted BMD loss. Please refer to Table S2 for a description of the functions of these genes and SNPs. Abbreviation: BMD, bone mineral density; HCT, hematopoietic cell transplantation; SNP, single nucleotide polymorphism.single nucleotide polymorphism.