Short-distance vesicle transport via phase separation. Qiu et al

Using the reconstituted presynaptic terminal local vesicle transport as a paradigm, Qiu and Wu et al. demonstrate that short-distance and directional vesicle transport can be achieved via regulated phase separation of vesicles with different protein condensates without involving molecular motors.以重构的突触前末梢（presynaptic terminal）局部囊泡运输（vesicle transport）为研究范式，邱与吴等人证实，短距离定向囊泡运输可通过囊泡与不同蛋白质凝聚体（protein condensates）的调控性相分离（phase separation）实现，且无需依赖分子马达（molecular motors）。