Semantic differential profile rating constructs.

Reward processing abnormalities in individuals with Major Depressive Disorder (MDD) alter motivation and hedonic responses, with greater impairments in those at risk of suicide. Preferred music is typically perceived as a rewarding and pleasurable experience that can influence motivation and emotion. Given its influential nature, evaluating how individuals with MDD and suicidal thoughts and behaviours respond to music could serve as a novel behavioural marker to indicate suicidality. This study aimed to evaluate reward response to music measured through the Barcelona Music Reward Questionnaire (BMRQ) and a semantic differential profile scale to investigate music reward and self-perception. Data were collected through the CAN-BIND 5 initiative at St. Michael’s Hospital, Toronto. Adults aged 18–68 years participated in this cross-sectional observational study. Participants included individuals with MDD with suicidal ideation and no attempt (SI/NA; n = 19), MDD with suicidal ideation and lifetime attempt (SI/LA; n = 14), MDD with no suicidal ideation and lifetime attempt (NSI/LA; n = 13), and healthy controls (HC; n = 28). Participants completed the BMRQ online within 48-hours of their baseline visit. During the in-person visit, they completed a 29-item semantic differential profile scale before and after listening to a preferred piece of music. BMRQ results showed no significant differences across groups for each factor and for overall scores. A two-way ANOVA with the semantic differential profile scale revealed a significant interaction effect between participant group and time points, F(3, 224) = 4.32, p = .006, η2 = 0.05. Post-hoc analysis using Tukey’s HSD test revealed the HC consistently had significantly higher semantic profile scores than all patient groups, both before and after listening to music (all p p