Crystal Structure of the ER-alpha Ligand-binding Domain (Y537S) in Complex with octane-1,8-diyl bis(2,3-bis(4-hydroxyphenyl)pentanoate)

Protein Data Bank Japan2024-03-06 更新2026-03-21 收录

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Crystal Structure of the ER-alpha Ligand-binding Domain (Y537S) in Complex with octane-1,8-diyl bis(2,3-bis(4-hydroxyphenyl)pentanoate) Descriptor: 8-{[2,3-bis(4-hydroxyphenyl)pentanoyl]oxy}octyl (2R,3S)-2,3-bis(4-hydroxyphenyl)pentanoate, Estrogen receptor, NUCLEAR RECEPTOR COACTIVATOR 2 Authors: Nwachukwu, J.C, Srinivasan, S, Bruno, N.E, Nowak, J, Kojetin, D.J, Elemento, O, Katzenellenbogen, J.A, Nettles, K.W. Deposit date: 2016-10-12 Release date: 2017-01-18 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (1.903 Å) Cite: Systems Structural Biology Analysis of Ligand Effects on ER alpha Predicts Cellular Response to Environmental Estrogens and Anti-hormone Therapies. Cell Chem Biol, 24, 2017

雌激素受体α（Estrogen Receptor alpha, ER-α）配体结合结构域（Y537S）与辛烷-1,8-二基双(2,3-双(4-羟基苯基)戊酸酯)复合物的晶体结构描述符：8-{[2,3-双(4-羟基苯基)戊酰基]氧基}辛基 (2R,3S)-2,3-双(4-羟基苯基)戊酸酯、雌激素受体、核受体辅激活因子2 作者：Nwachukwu, J.C、Srinivasan, S、Bruno, N.E、Nowak, J、Kojetin, D.J、Elemento, O、Katzenellenbogen, J.A、Nettles, K.W. 存档日期：2016-10-12 发布日期：2017-01-18 最后修改日期：2024-03-06 实验方法：X射线衍射（分辨率1.903埃）引用：《配体对ERα影响的系统结构生物学分析可预测细胞对环境雌激素与抗激素治疗的响应》，《Cell Chemical Biology（Cell Chem Biol）》，24卷，2017年

创建时间：

2016-10-12