Expression of GATA4 in cardiogenesis

The GATA4 gene is transcribed to yield mRNA and the mRNA is translated to yield GATA4 protein (inferred from mouse homologs). MESP1 binds the promoter of the GATA4 gene and activates transcription (inferred from mouse homologs). GATA4 is expressed in MESP1-positive cardiac progenitors (den Hartogh et al. 2016) of both the first heart field and second heart field (inferred from mouse homologs). After activation by MESP1, GATA4 is regulated by NKX2-5 (Riazi et al. 2009).

GATA4基因经转录生成mRNA，该mRNA进一步翻译形成GATA4蛋白（依据小鼠同源基因推断）。MESP1结合GATA4基因的启动子并激活转录（依据小鼠同源基因推断）。GATA4在MESP1阳性的心脏祖细胞（den Hartogh等，2016年）中表达，这些细胞既属于第一心脏场，也属于第二心脏场（依据小鼠同源基因推断）。在MESP1激活后，GATA4的表达受到NKX2-5的调控（Riazi等，2009年）。