Crystal structure of E. coli class Ia ribonucleotide reductase alpha subunit W28A variant bound to dATP and ATP

Crystal structure of E. coli class Ia ribonucleotide reductase alpha subunit W28A variant bound to dATP and ATP Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... Authors: Funk, M.A, Zimanyi, C.M, Drennan, C.L. Deposit date: 2024-01-02 Release date: 2024-09-04 Last modified: 2026-03-04 Method: X-RAY DIFFRACTION (3.4 Å) Cite: How ATP and dATP Act as Molecular Switches to Regulate Enzymatic Activity in the Prototypical Bacterial Class Ia Ribonucleotide Reductase. Biochemistry, 63, 2024大肠杆菌Ia类核糖核苷酸还原酶α亚基W28A变异体结合2'-脱氧腺苷5'-三磷酸（2'-DEOXYADENOSINE 5'-TRIPHOSPHATE，dATP）与腺苷-5'-三磷酸（ADENOSINE-5'-TRIPHOSPHATE，ATP）的晶体结构 配体描述：2'-脱氧腺苷5'-三磷酸、腺苷-5'-三磷酸、镁离子…… 作者：Funk, M.A.、Zimanyi, C.M.、Drennan, C.L. 提交日期：2024-01-02 发布日期：2024-09-04 最后修改日期：2026-03-04 实验方法：X射线衍射（分辨率3.4埃） 引用文献：《ATP与dATP作为分子开关调控典型细菌Ia类核糖核苷酸还原酶的酶活性》，《生物化学》，第63卷，2024年