LMDP cleavage by γ-secretase.
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(a) γ-secretase activity in cultured cells. The fluorescence peptide probe was incubated with membrane fractions from HUEhT-2, HeLa, MCF-7 and A549 cells. (b) Competitive inhibition of LMDP. The peptide probe and LMDP were incubated at the indicated concentrations in the membrane fraction of A549 cells at 37°C overnight. Values and bars represent the means and SD, respectively. (c) Representative chromatograms of LMDP with or without the membrane fraction as determined by HPLC analysis from three independent experiments. *, P
创建时间：
2016-02-23
