Data supporting: "Anti-Polyamine Therapy Restrains Kidney Cyst Growth in an Orthologous Mouse Model of Autosomal Dominant Polycystic Kidney Disease"

This dataset contains processed bulk RNA-seq count and expression matrices, differential gene expression (DGE) results, pathway analysis, and cell type deconvolution outputs generated in support of manuscript titled "Anti-Polyamine Therapy Restrains Kidney Cyst Growth in an Orthologous Mouse Model of Autosomal Dominant Polycystic Kidney Disease". DGE analysis was performed using PyDESeq2. Pathway analysis was performed using decoupleR against MSigDB gene sets (KEGG and Hallmark collections; accessed October 2025). Cell type deconvolution was performed using CIBERSORTx with a mouse kidney single-cell RNA-seq reference dataset (GEO accession: GSE268494). Analysis code is available on GitHub: https://github.com/SizhaoLu/RC_DFMO_analysis_2026 Files count.csv Raw read count matrix from bulk RNA-seq (genes × samples) RCvB6_DGE.csv DEG results: RC vs B6 (PyDESeq2 output) DFMOvRC_DGE.csv DEG results: DFMO vs RC (PyDESeq2 output) RCvB6_DGE_PW.csv Pathway analysis results: RC vs B6 DFMOvRC_DGE_PW.csv Pathway analysis results: DFMO vs RC rescue_genes_merged_log2fc.csv Merged log₂ fold-change values for scatter plot cibersortx_bulk_DFMO.txt Bulk RNA-seq input file formatted for CIBERSORTx CIBERSORTx_Job4_Results.csv Cell type deconvolution results from CIBERSORTx