An atlas of genetic influences on osteoporosis in humans and mice

In our study, we leveraged RNA-seq data from four different human osteoblast cell lines and ATAC-seq data from one human osteoblast cell line to identify target genes for plausibly causal SNPs influencing bone density. We also re-called ENCODE generated osteoblast DNase hypersensitive sites, and have uploaded them here for sharing. Overall design: RNA-seq in four human osteoblast cell lines and ATAC-seq in one human osteoblast cell line. DHS re-called from ENCODE primary osteoblast data. Dnase-seq data obtained from ENCODE under accessions ENCLB776DWN and ENCLB906BCL