Figure 6

<b>Figure 6:</b> <b>p5555kb-derived antibodies cross the blood-brain barrier.</b><b>(A)</b> Immunoblots showing recombinant human tau 2N4R monomers (Human 2N4R), human 2N4R PFF (Human PFF) and human P301S mutant tau filaments (Human P301S) probed with commercially available anti-tau antibody (HT7), brain homogenate from a mouse immunized with p5555kb (p5555kb), or brain homogenate from a mouse injected with saline (Vehicle). This image contains 3 membranes that were probed separately but imaged together under the same exposure settings. <b>(B)</b> Immunoblots showing recombinant human tau probed with brain homogenate from a mouse immunized with p5555kb (Brain) and the serum fraction of the terminal blood sample from the same mouse (Blood). This image contains 2 membranes that were probed separately but imaged together under the same exposure settings.