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α-Ketoglutarate attenuates Wnt signaling and drives differentiation in colorectal cancer. α-Ketoglutarate attenuates Wnt signaling and drives differentiation in colorectal cancer

NIAID Data Ecosystem2026-03-11 收录

结直肠癌Wnt信号通路

代谢物诱导分化

数据链接：

https://www.ncbi.nlm.nih.gov/bioproject/PRJNA589064 数据链接链接失效反馈

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资源简介：

This SuperSeries is composed of the SubSeries listed below. Overall design: Refer to individual Series

应用场景：

创建时间：

2019-11-12

结直肠癌Wnt信号通路

类器官疾病模型

Constitutive Wnt activation upon loss of Adenoma polyposis coli (APC) acts as main driver of colorectal cancers (CRC). Targeting Wnt signaling has proven difficult because the pathway is crucial for h

NIAID Data Ecosystem30

hSETD1A cooperates with beta-catenin to regulate Wnt target genes and control colorectal tumor growth

结直肠癌Wnt信号通路

基因表达调控

Glioblastoma multiforme (GBM) is the most prevalent type of adult brain tumor, and one of the deadliest tumors known to mankind. The genetic understanding of GBM is, however, limited, and the molecula

NIAID Data Ecosystem10

The Notch-2 Gene Is Regulated by Wnt Signaling in Cultured Colorectal Cancer Cells

结直肠癌Wnt信号通路

Notch通路基因调控

BackgroundNotch and Wnt pathways are key regulators of intestinal homeostasis and alterations in these pathways may lead to the development of colorectal cancer (CRC). In CRC the Apc/β-catenin genes i

NIAID Data Ecosystem10

Insights into carcinogenic mechanisms of colorectal carcinoma lacking β-catenin/TCF regulated transcription.

结直肠癌Wnt信号通路

转录调控机制

We sought to identify the carcinogenic mechanisms involved in RKO cell line with no evidence of activated β-catenin/TCF regulated transcription, by comparison its gene expression profile to that of gr

NIAID Data Ecosystem20

Genetic and Proteomic Screening Reveals ß-catenin-dependent Transcriptional Regulation in Colorectal Cancer

结直肠癌Wnt信号通路

β-catenin转录调控

Colorectal cancer is one of the most commonly diagnosed and deadly cancers. Aberrant activation of the canonical Wnt pathway is observed in virtually all CRC patients. Despite intense efforts, most of

Monash University Figshare2026-02-11 更新10

α-Ketoglutarate attenuates Wnt signaling and drives differentiation in colorectal cancer. α-Ketoglutarate attenuates Wnt signaling and drives differentiation in colorectal cancer

资源简介：

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