Adverse effect of folic acid supplementation on cilia

We report that fortified levels of folic acid adversely affect cilia strucure and function. This data set agrees with previous experiements which have demonstrated that elevated folic acid levels can increase transcription variability on a genome-wide level. Furthermore, we demonstrate that among these dysregulated genes, genes contained within SYSgold cilia database are proportionally over-represented. This over-representation of cilia genes among dysregulated genes may play a key role in ciliopathys' sensitivity to elevated folic acid levels. Overall design: Examination of mice fed two levels of folic acid (moderate[8 samples] and enriched[8samples]) that are either WT(4 samples per diet) or homozygous IFT88-null (4 samples per diet)