Salamander: First estimations of SPR variability and the errors introduced by linearization and loss of spatial resolution.

Deterministic simulations with R* lifetimes τav and 2τav, using the FSR, TWS and GWS models. Δ% is relative difference of the outputs for each pair of runs. Computation of , and the maximum value of E*(t) as defined by Eqs 14 and 15 for each of these two runs. Computation of I(tpeak) using the nonlinear relations of Eqs 1 and 2 and Ilin(tpeak) using the linearization Eq 17 for the cGMP component of the current and the nonlinear relation Eq 2 for Jex. , and are independent of the linearization Eq 17.