Gene expression profile during Ebselen treatment in budding yeast

Ebselen is synthetic selenium containing organic compound. It exhibits glutathione peroxidase (GSH-Px) like activity hence acts as a potent antioxidant therefore has been widely used in the treatment of various diseases. In contrast, certain studies also demonstrate its toxic nature; however its mechanism of action is not well understood. Presently, Ebselen has been used at 100 µM concentration for the elucidation of its molecular and cellular mechanism of action. Microarray analysis identified the differentially expressed genes in 100 µM Ebselen concentration.依布硒啉（Ebselen）是一种含硒合成有机化合物。其具有谷胱甘肽过氧化物酶（glutathione peroxidase，GSH-Px）样活性，可作为强效抗氧化剂，因此被广泛应用于多种疾病的治疗。与之相对，部分研究亦证实其具有毒性；然而其具体作用机制尚未被充分阐明。目前，科研人员以100 µM的依布硒啉浓度开展实验，以阐明其分子与细胞层面的作用机制。基因芯片分析（microarray analysis）鉴定出了100 µM依布硒啉处理条件下的差异表达基因。