Interaction of neutrophils and hepatic stellate cells promotes fibrosis in a mouse model of steatohepatitis. Mus musculus

Our current study proved a synergistic effect of obesity and binge drinking on liver fibrosis, which is partially mediated via the interaction of neutrophils and HSCs. Controlling the infiltration of neutrophils as well as the interplay between neutrophils and HSCs may be a novel therapeutic intervention to prevent liver fibrosis in steatohepatitis. Overall design: Four-condition experiment, Chow+maltose, Chow+one binge, HFD+maltose, HFD+one binge