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Synthesis of a Masked 2,3-Diaminoindole

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Figshare2016-12-01 更新2026-04-29 收录
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A three-step synthesis of masked 2,3-diaminoindole 1 from 2-iodo-3-nitro-1-(phenylsulfonyl)­indole (2) has been developed. Treatment of 1 with trifluoroacetic acid generates the unstable 2,3-diamino-1-(phenylsulfonyl)­indole (3), which can be trapped with α-dicarbonyl compounds to afford 5H-pyrazino­[2,3-b]­indoles 7–10.

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2016-12-01
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