Statistical comparison of the photopic visual functions of +/+, P14-treated and untreated GC1KO mouse eyes as measured by optomotor behavior.

Under photopic conditions, P14 treatment with either AAV5-smCBA-mGC1 or AAV5-hGRK1-mGC1 produces acuity and contrast sensitivity similar to normal GC1+/+ animals. Treated eyes have significantly better acuity and contrast sensitivity than untreated GC1KO eyes. Each mouse was tested for 4–6 trials per condition. Data from each animal was then averaged to obtain the means for each condition. The standard deviation listed is the standard deviation of the individual mouse means. P-values were calculated using an unpaired t-test. *P<0.0001.