Crystal structure of Candida albicans acetohydroxyacid synthase in complex with the herbicide metosulam

Crystal structure of Candida albicans acetohydroxyacid synthase in complex with the herbicide metosulam Descriptor: (3Z)-4-{[(4-AMINO-2-METHYLPYRIMIDIN-5-YL)METHYL]AMINO}-3-MERCAPTOPENT-3-EN-1-YL TRIHYDROGEN DIPHOSPHATE, 2-{3-[(4-AMINO-2-METHYLPYRIMIDIN-5-YL)METHYL]-4-METHYL-2-OXO-2,3-DIHYDRO-1,3-THIAZOL-5-YL}ETHYL TRIHYDROGEN DIPHOSPHATE, Acetolactate synthase, ... Authors: Garcia, M.D, Guddat, L.W. Deposit date: 2018-05-12 Release date: 2018-09-26 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.126 Å) Cite: Commercial AHAS-inhibiting herbicides are promising drug leads for the treatment of human fungal pathogenic infections. Proc. Natl. Acad. Sci. U.S.A., 115, 2018

白色念珠菌（Candida albicans）乙酰羟酸合酶（acetohydroxyacid synthase, AHAS）与除草剂甲氧磺草胺（metosulam）复合物的晶体结构。数据集描述项：(3Z)-4-{[(4-氨基-2-甲基嘧啶-5-基)甲基]氨基}-3-巯基戊-3-烯-1-基三氢二磷酸酯、2-{3-[(4-氨基-2-甲基嘧啶-5-基)甲基]-4-甲基-2-氧代-2,3-二氢-1,3-噻唑-5-基}乙基三氢二磷酸酯、乙酰乳酸合酶（Acetolactate synthase）等。作者：Garcia M.D.、Guddat L.W.。提交日期：2018-05-12；发布日期：2018-09-26；最后修改日期：2023-10-11。解析方法：X射线衍射（X-RAY DIFFRACTION，分辨率2.126 Å）。引用说明：商业化AHAS抑制剂类除草剂有望成为治疗人类真菌致病性感染的潜在药物先导化合物。《美国国家科学院院刊》（Proc. Natl. Acad. Sci. U.S.A.），115卷，2018年。