Potentiation of MEKi efficacy by the estrogen receptor antagonist Fulvestrant in ERα-positive cancer cell lines.
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https://figshare.com/articles/dataset/_Potentiation_of_MEKi_efficacy_by_the_estrogen_receptor_antagonist_Fulvestrant_in_ER_945_positive_cancer_cell_lines_/166149
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The predicted additive effect was determined by applying the Bliss additivity model§[25]. A greater than additive or synergistic interaction (observed effect exceeds the expected effect) was noted only in the ERα- expressing cell lines, SKOV3 and Ishikawa. Conversely, A2780, ERα-negative ovarian carcinoma cells exhibited antagonism between MEKi and fulvestrant.
¶As determined by SRB assay.
创建时间：
2013-02-04
