Linear regression of the secondary outcome on blood biomarker measures and covariates.

BDI-II = Beck Depression Inventory II. β = standardized regression coefficient. hs-CRP = high-sensitivity C-reactive protein. IL-6 = interleukin-6. R2 = coefficient of determination. R2adjusted = adjusted coefficient of determination. RMSE = root-mean-square error. S-100B = S-100 calcium-binding protein B. *Delayed Δ refers to the secondary outcome, delayed change in depressive symptom severity, defined as the intra-subject difference between BDI-II scores at baseline and six-month follow-up †Corresponds to the blood biomarker term in the model. ‡Within 7 days before the index procedure. Linear regression of the secondary outcome on blood biomarker measures and covariates.