Crystal structure of insulin receptor kinase domain in complex with cis-(R)-7-(3-(azetidin-1-ylmethyl)cyclobutyl)-5-(3-((tetrahydro-2H-pyran-2-yl)methoxy)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine.

Crystal structure of insulin receptor kinase domain in complex with cis-(R)-7-(3-(azetidin-1-ylmethyl)cyclobutyl)-5-(3-((tetrahydro-2H-pyran-2-yl)methoxy)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine. Descriptor: 1,2-ETHANEDIOL, 7-[3-(azetidin-1-ylmethyl)cyclobutyl]-5-[3-[[(2~{R})-oxan-2-yl]methoxy]phenyl]pyrrolo[2,3-d]pyrimidin-4-amine, Insulin receptor Authors: Scheufler, C, Izaac, A, Stauffer, F. Deposit date: 2016-01-11 Release date: 2016-04-13 Last modified: 2024-05-01 Method: X-RAY DIFFRACTION (1.79 Å) Cite: Identification of a 5-[3-phenyl-(2-cyclic-ether)-methylether]-4-aminopyrrolo[2,3-d]pyrimidine series of IGF-1R inhibitors. Bioorg.Med.Chem.Lett., 26, 2016

胰岛素受体激酶结构域与顺式-(R)-7-(3-(氮杂环丁烷-1-基甲基)环丁基)-5-(3-((四氢-2H-吡喃-2-基)甲氧基)苯基)-7H-吡咯并[2,3-d]嘧啶-4-胺复合物的晶体结构。描述项：1,2-乙二醇、7-[3-(氮杂环丁烷-1-基甲基)环丁基]-5-[3-[[(2R)-四氢-2H-吡喃-2-基]甲氧基]苯基]吡咯并[2,3-d]嘧啶-4-胺、胰岛素受体。作者：Scheufler, C、Izaac, A、Stauffer, F。提交日期：2016-01-11。发布日期：2016-04-13。最后修改日期：2024-05-01。实验方法：X射线衍射（分辨率1.79埃）。引用文献：《5-[3-苯基-(2-环醚)-甲醚]-4-氨基吡咯并[2,3-d]嘧啶类胰岛素样生长因子1受体（IGF-1R）抑制剂的发现》，《Bioorg.Med.Chem.Lett.》，2016年，第26卷。