Crystal Structure of Human Glycine Receptor alpha-3 Mutant N38Q Bound to AM-3607, Glycine, and Ivermectin

Crystal Structure of Human Glycine Receptor alpha-3 Mutant N38Q Bound to AM-3607, Glycine, and Ivermectin Descriptor: (2aE,4E,5'S,6S,6'R,7S,8E,11R,13R,15S,17aR,20R,20aR,20bS)-6'-[(2S)-butan-2-yl]-20,20b-dihydroxy-5',6,8,19-tetramethyl-17 -oxo-3',4',5',6,6',10,11,14,15,17,17a,20,20a,20b-tetradecahydro-2H,7H-spiro[11,15-methanofuro[4,3,2-pq][2,6]benzodioxacy clooctadecine-13,2'-pyran]-7-yl 2,6-dideoxy-4-O-(2,6-dideoxy-3-O-methyl-alpha-L-arabino-hexopyranosyl)-3-O-methyl-alpha-L-arabino-hexopyranoside, (3S,3aS,9bS)-2-[(2H-1,3-benzodioxol-5-yl)sulfonyl]-3,5-dimethyl-1,2,3,3a,5,9b-hexahydro-4H-pyrrolo[3,4-c][1,6]naphthyridin-4-one, GLYCINE, ... Authors: Shaffer, P.L, Huang, X, Chen, H. Deposit date: 2017-04-03 Release date: 2017-05-24 Last modified: 2024-11-20 Method: X-RAY DIFFRACTION (3.1 Å) Cite: Crystal Structures of Human GlyR alpha 3 Bound to Ivermectin. Structure, 25, 2017

本数据集为结合AM-3607、甘氨酸与伊维菌素的人源甘氨酸受体α-3突变体N38Q的晶体结构。数据集描述如下：包含分子(2aE,4E,5'S,6S,6'R,7S,8E,11R,13R,15S,17aR,20R,20aR,20bS)-6'-[(2S)-丁-2-基]-20,20b-二羟基-5',6,8,19-四甲基-17-氧代-3',4',5',6,6',10,11,14,15,17,17a,20,20a,20b-十四氢-2H,7H-螺[11,15-甲撑呋喃并[4,3,2-pq][2,6]苯并二氧环十八碳烯-13,2'-吡喃]-7-基 2,6-二脱氧-4-O-(2,6-二脱氧-3-O-甲基-α-L-阿拉伯型己吡喃糖苷)-3-O-甲基-α-L-阿拉伯型己吡喃糖苷、(3S,3aS,9bS)-2-[(2H-1,3-苯并二氧戊环-5-基)磺酰基]-3,5-二甲基-1,2,3,3a,5,9b-六氢-4H-吡咯并[3,4-c][1,6]萘啶-4-酮以及甘氨酸（GLYCINE）。作者：Shaffer, P.L.、Huang, X.、Chen, H. 提交日期：2017-04-03；发布日期：2017-05-24；最后修改日期：2024-11-20；解析方法：X射线衍射（3.1 Å）；引用文献：《结合伊维菌素的人源甘氨酸受体α3晶体结构》（Crystal Structures of Human GlyR α3 Bound to Ivermectin），《Structure》，第25卷，2017年。