CRYSTAL STRUCTURES OF NK1-HEPARIN COMPLEXES REVEAL THE BASIS FOR NK1 ACTIVITY AND ENABLE ENGINEERING OF POTENT AGONISTS OF THE MET RECEPTOR

CRYSTAL STRUCTURES OF NK1-HEPARIN COMPLEXES REVEAL THE BASIS FOR NK1 ACTIVITY AND ENABLE ENGINEERING OF POTENT AGONISTS OF THE MET RECEPTOR Descriptor: 2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose, 2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid, 2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid, ... Authors: Lietha, D, Chirgadze, D.Y, Mulloy, B, Blundell, T.L, Gherardi, E. Deposit date: 2001-09-20 Release date: 2001-10-02 Last modified: 2024-11-06 Method: X-RAY DIFFRACTION (3 Å) Cite: Crystal Structures of Nk1-Heparin Complexes Reveal the Basis for Nk1 Activity and Enable Engineering of Potent Agonists of the met Receptor Embo J., 20, 2001

本数据集主题为NK1-肝素复合物的晶体结构，其揭示了NK1发挥活性的分子基础，并可用于工程化构建MET受体的强效激动剂。数据集描述的多糖配体序列如下：
1. 2-O-磺基-α-L-艾杜吡喃糖醛酸(2-O-sulfo-alpha-L-idopyranuronic acid)-(1→4)-2-脱氧-6-O-磺基-2-(磺酰胺基)-α-D-吡喃葡萄糖(2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose)-(1→4)-2-O-磺基-α-L-艾杜吡喃糖醛酸(2-O-sulfo-alpha-L-idopyranuronic acid)-(1→4)-2-脱氧-6-O-磺基-2-(磺酰胺基)-α-D-吡喃葡萄糖(2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose)-(1→4)-2-O-磺基-α-L-艾杜吡喃糖醛酸(2-O-sulfo-alpha-L-idopyranuronic acid)-(1→4)-2-脱氧-6-O-磺基-2-(磺酰胺基)-α-D-吡喃葡萄糖(2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose)
2. 2-O-磺基-α-L-艾杜吡喃糖醛酸(2-O-sulfo-alpha-L-idopyranuronic acid)-(1→4)-2-脱氧-6-O-磺基-2-(磺酰胺基)-α-D-吡喃葡萄糖(2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose)-(1→4)-2-O-磺基-α-L-艾杜吡喃糖醛酸(2-O-sulfo-alpha-L-idopyranuronic acid)-(1→4)-2-脱氧-6-O-磺基-2-(磺酰胺基)-α-D-吡喃葡萄糖(2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose)-(1→4)-2-O-磺基-α-L-艾杜吡喃糖醛酸(2-O-sulfo-alpha-L-idopyranuronic acid)-(1→4)-2-脱氧-6-O-磺基-2-(磺酰胺基)-α-D-吡喃葡萄糖(2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose)-(1→4)-2-O-磺基-α-L-艾杜吡喃糖醛酸(2-O-sulfo-alpha-L-idopyranuronic acid)
3. 2-脱氧-6-O-磺基-2-(磺酰胺基)-α-D-吡喃葡萄糖(2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose)-(1→4)-2-O-磺基-α-L-艾杜吡喃糖醛酸(2-O-sulfo-alpha-L-idopyranuronic acid)-(1→4)-2-脱氧-6-O-磺基-2-(磺酰胺基)-α-D-吡喃葡萄糖(2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose)-(1→4)-2-O-磺基-α-L-艾杜吡喃糖醛酸(2-O-sulfo-alpha-L-idopyranuronic acid)-(1→4)-2-脱氧-6-O-磺基-2-(磺酰胺基)-α-D-吡喃葡萄糖(2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose)-(1→4)-2-O-磺基-α-L-艾杜吡喃糖醛酸(2-O-sulfo-alpha-L-idopyranuronic acid)
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作者：Lietha, D、Chirgadze, D.Y、Mulloy, B、Blundell, T.L、Gherardi, E
提交日期：2001年9月20日
发布日期：2001年10月2日
最后修改日期：2024年11月6日
实验方法：X射线衍射（分辨率3埃）
引用文献：《NK1-肝素复合物的晶体结构揭示NK1活性的分子基础并可用于构建MET受体强效激动剂》，发表于《欧洲分子生物学组织期刊（EMBO J.）》，第20卷，2001年。